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2019-04-19 10:20:48

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  WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.

  MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.

  Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  “Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”

  Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.

  MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.“Shock–that’swhatIrememberfeelingwhenIheardthediagnosis.Ihadbeenhealthyallmylife,workedoutdoorsfor40yearswithoutanysignsofskindamage.Iplayedbasketballthreetimesaweek.Iwasfifty-eight,butIfelttenyearsyounger.Suddenly,thefutureIhadenvisionedformyselfseemedtobeslippingaway.IwasafraidIwouldn’tlivetoseemysixtiethbirthday.”Bensoonlearnedthatthecancerwasinbothshoulders,hislungs,kidneyandliver.Itwasalsobreakinghisbones:rightscapula,leftclavicle,andthreebonesinhisthoracicspine…Allbroken.Hewasweakerandsickerthanhehadeverimaginedpossible.Buthewasn’tgivingin.TogetherwithJudy,hissistersJackieandMarsha,andhisdaughters,Bensethissightsonbeatingmelanoma.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”

  WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”Wemustdomore.That’swhyMSDisfocusingourexpertiseincancerresearchonfindingnewoptionsforkidneycancer.Wehaveanimportantchallengeaheadofus–toidentifynewwaystohelptheseindividualsandtheirfamilies.Wearebreakingnewgroundinourquesttodevelopnewtreatmentstobringoptionstopeoplewithadvancedkidneycancer.Thisstartsbyapplyingwhatwe’velearnedinotherareasofcancerresearch.Acrossouroncologyresearchteam,MSDistakingalookatadvancedkidneycancertoinnovatenewapproachestofightingthisdisease.AddsDr.Ebbinghaus,“Wearecommittedtodedicatingourfullexpertisetoadvancingresearchinthischallengingtreatmentsetting.Ourgoalistodeveloppractice-changingtherapiesforpatientsinneedofnewoptions.”

  Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”Twostrangersmeetataraceandconnectovercommongroundtosaveandimprovewomen’slives."Ilovetorun,butmorethanthat,IlovemeetingpeoplewhoareaspassionateasIamaboutsavingandimprovinglives,"saysPamPolino,executivedirector,scientificaffairsatMSD."That’swhyIheadedstraightovertotheMilesforMotherstentassoonasthe5Kracewasover."ItwastherethatPammetDeboraBossemeyer,globalprogramleaderforJhpiego,anonprofithealthorganizationandJohnsHopkinsUniversityaffiliatethatpartnerswithMSDandothercompaniestosavelives,improvehealthandtransformthefutureofwomenandtheirfamilies.Althoughmaternalmortalityhasdeclinedinthepastdecade,theWorldHealthOrganizationestimatesthat830womenaroundtheworlddieeverydayfrompreventablecausesrelatedtochildbirthandpregnancy.Jhpiegoandothersareworkingtochangethosestatistics.“Nowomanshoulddiegivinglifejustbecauseshelivesinapoorcountry,”saysDebora.

  StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”

  RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.StreamliningthehuntfornewdrugcandidatesRecently,ourDiscoveryteamsdiscoverednewmethodstotestthepotencyofnewcompounds,alsousingaminiaturizedplatform.Thisnewapproachishundredsoftimesfasterthanexistingmethodsandusesverysmallamountsofmaterial(thisinventionandearlyresultswerehighlightedintheprestigiousscientificpublicationNature).BerengereSauvagnat,anassociateprincipalscientist,Pharmacology,wastheco-authorontheNaturearticleandoneoftheprimaryresearchersonthisnewprocess.“Bymergingourminiaturizedsynthesisplatformwithabiochemicalassay,wehopetostreamlinethehuntfornewdrugcandidates,”shenotes.“Weareexcitedbyearlyevidencesuggestingthatweareonapathtoreducingthenumberofstepsinthedrugdiscoveryprocess.”Whenprostatecanceriscaughtearly,itgenerallyhasabettersurvivalrate.But,forthosemenwithlocallyadvancedormetastaticprostatecancer,theoutcomescanbedramaticallydifferent.AtMSD,wearefocusedontryingtodomoreforthesemen.“Weareinthemidstofbuildingoneofthelargestandmostcomprehensiveresearchprogramsinprostatecancerintheindustry.Ourgoalistofindnewtreatmentapproachesacrossallsettingsofprostatecancerwherethereistremendousneedfornewtherapies.”

  AJOURNEYACROSSTHEHEALTHCARELANDSCAPERaqueljoinedthecompanyinSpainin2010,takingonvariousleadershiproleswithinthehospitalandspecialtybusinessunit.In2016,shewasappointedtohercurrentU.S.-basedroleleadingthemarketingteamsforhospitalandspecialtyintheU.S.market.Duringhercareer,she’sworkedinfourdifferentcompanies,launchedsevennewproductsandlivedintheU.K.,France,Spainandnow,theU.S.“Diverseexperienceshelpedmeunderstandtheuniquenessofthehealthcarelandscapeindifferentpartsoftheworld,”shesays.“Theseinsightshavebeenveryhelpfulinmycurrentrole,whereweareworkingonsometoughquestions:HowdoweusetechnologyinnewwaystocreateabettercustomerexperienceHowdoweensurepatientinsightsarebuiltintoeverydecisionWhatmustwedoasacompanytocontinuedeliveringvaluetopatientsandsociety”RESILIENCEANDCOURAGEGeralyngraduatedfromStanfordLawSchoolandDukeUniversityandhasamaster’sdegreeininternationaleconomics.Shebeganhercareeratalawfirmandlaterservedinthegovernmentasanintellectualpropertylawyer.Next,sheworkedastheheadofInternationalAffairsforPhRMA,leadingindustryadvocacywithgovernmentsaroundtheworld.GeralynjoinedMSDin2008toleadthecompany’sGlobalPublicPolicyorganization.OneofherproudestaccomplishmentswaslaunchingMSDforMothers.Inhercurrentlegalrole,Geralynadvisesthecompany’sexecutivesandboardofdirectorsoncorporategovernancemattersandengageswithmajorinvestors.DOINGOURPARTFORCOMMUNITIESAlongwithconservingwaterandmanagingwastewateratourfacilities,ourcompanyhassupportedwaterimprovementprojectsinthecommunitieswhereourfacilitiesarelocated.Forexample,wehelpedsupportaprojecttoprotecttheAtchafalayaRiverBasininLouisiana,whichstretchesfromLouisianatotheGulfofMexico.Thebasinishomefor250speciesofbirds,100speciesoffish,millionsofpoundsofcrawfish,reptiles,raccoons,blackbearsandmore.“Thebasinisabigpartofoureconomy,ourrecreationandthehealthofourcommunity,”saysRobertSnowden,alife-longLouisianaresidentandaspecialistinsafetyandenvironmentforouranimalhealthbusiness.“Fishingandhuntingarehugehere.Ifwedon’ttakecareofthewaterways,fishandotherorganismswilldie,andthewildlifethatdependontheecosystemswillbeindangeraswell.Inturn,familieswhodependonfishandgameforfoodandincomewillsuffer.”

  MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.MobilizingaCareerOvertheyears,CarolinehascombinedherflareforfinanceandbusinessacumenwithrolesthatenabledhertolearnandimpactallaspectsofMSD’sbusinessacrosscountries,regionsandatglobalheadquarters.InadditiontothelastfewyearsleadingFinanceforGHHandtheEmergingMarketsandEuropeanregionswithinGHH,CarolinehasheldfinancesupportrolesinMSDManufacturingDivisionandMSDResearchLaboratoriesandatthecompany’ssitesglobally.She’srecognizedasanexpertinfinancialplanning,resourceallocation,financialreportingandcompliance–andasafierceadvocateforMSD’smissionintheworld.Alloftheabovepropelledhertowardhernewestroleasourcompanytreasurer,responsibleforTax,TreasuryandInvestorRelations,effectiveJan.1,2019.“Thisisagreatopportunitytobroadenmyskillset,buildingonmystrengthswhilehelpingMSDtodeliverontheexpectationsofourcustomersandinvestors,”saysCaroline.

  Beclearaboutwhatyouwant.Don’tbeafraidofchallenges,anddon’tgiveupeasily.”“Findasenseofpurposeandwhatyouarepassionateabout,planyourlifeandseekoutnewchallenges.Forme,livingandworkinginandwithdifferentculturalenvironmentsbroadenedmyperspectives–personallyandprofessionally.BeingbasedintheU.S.forglobalmarketingrolesenabledmetoworktogetherwithdifferentteamsworldwide.WorkingandlivingindifferentEuropeancountries,Iamstillfascinatedbytheculturalvarietydespiterelativegeographicproximity.Insomecountries,youneedtocomestraighttothepoint,inothers,youneedmorerelationshipbuilding,andinsomeplaces,youwillneedtobecomemasterofimprovisation.Thisexperienceenabledmenotonlytoadjustmyleadershipstylebutalsotoappreciatethevalueofdifferentapproachesandlisteningtodiversethoughtstomakebetterdecisions.”WhenyouorIthinkaboutmedicine,wemayjustthinkaboutwhatlinesourbathroomcabinet.But,medicinesactuallycomeinavarietyofformsandcanbeadministeredinavarietyofways.And,whilethesemedicinesareverypowerfulintheirabilitytohealpeoplefromdevastatingillnesses,theyarealsosometimesveryfragileintheirchemicalstability,impactingtheirabilitytobetransportedtoremotelocationswhilestillmaintainingpotency.Inordertoremaineffective,theymayrequirerefrigerationorsmoothtransport--meaning,theymusttraveltoaclinicorahospitaloradoctorsofficeonpavedroadsinthesafetyofanenclosed,cooltruckandnot,say,daysthroughdusty,hotterraininathirdworldcountry.AsexecutivedirectorofMSD'sPreformulationGroup,JasonCheungplaysanimportantroleinmakingsureourmedicinescanbemanufacturedconsistentlyandmaintaintheirstabilitysothattheycangettothepatientswhoneedthem,whereeverintheworldtheymaybe.Ourgoalistobuildfoundationalknowledgeonmechanismsthatmaintainproductstabilityandeffectiveness.Understandingthesemechanismssupportsourabilitytodeliverinnovativemedicinesacrosstheglobe,explainsJason.ThereeverystepofthejourneyTheirworkbeginsintheearlystagesoftheresearchanddevelopmentjourney--longbeforeourdrugcandidatesaretestedaspotentialmedicinesinclinicaltrials--andcontinuesuntiltheyhaveaproductthatissuitableforlarge-/commercial-scalemanufacturing.Whenmedicinesfinallybecomeavailabletopatients,they'vealreadyundergoneachallengingjourney,hesays.Ourmedicinesarecreatedeitherthroughcomplexchemistryorbymanipulatinglivingcellstoexpressproteins.Inbothcases,westartwithverysmallscalesandvolumes(thinkmL)andultimatelyproducethematscalesthatarethousandsofliters.Inadditiontoquantityincreases,anotherchallengeforJasonandhisteamisfiguringouthowtomaintainqualityandstabilitythroughoutthephysicaljourneyofourmedicines.Wetransportthesefromonelabtoanotherandfromourmanufacturingfacilitiestoclinicsallovertheworldduringdifferentmomentsintestingandtrials.Andtheyhavetobeabletowithstandthatkindofmovement.AproblemsolverWhenaskedifhegotintothislineofworkbecausehelikestosolveproblems,Jasondoesnthesitate.Oh,Ithinkallscientistsgetintothisbecausetheyliketosolveproblems,hesaid,resolutely.AndwhatssocoolaboutworkingatMSDisthattheproblemsolvingwedo,ourresearchusingcutting-edgetechnologyandscience,resultsinpositiveimpacttopeople'slivesandtheirqualityoflife.It’saveryrewardingexperience.MSDannouncedfourth-quartersalesofbillionworldwide–anincreaseof5percent,includinga3percentnegativeimpactfromforeignexchange.Full-yearworldwidesalesfor2018totaled.3billion,markingmeaningfulgrowthwitha5percentincrease.Fourth-quarterpharmaceuticalsalesincreased6percentto.8billion,largelydrivenbygrowthinoncologyandvaccines.ThecontinuedstrengthofKEYTRUDAsalessignalsthecompany’splaceasaleaderinimmuno-oncology.Thecompanyanticipatesfull-year2019worldwidesalestobebetween.2billionand.7billion,includinganapproximately1percentnegativeimpactfromforeignexchange.MSDenters2019withconfidenceinourkeygrowthpillarsofoncology,vaccines,AnimalHealthandselecthospitalandspecialtycareproducts.Thecompanycontinuestoinventforlifewithimpactfulresultsforpatientsandshareholders.Takealookattheinfographicbelowformoredetailsonfourth-quarterandfull-yearresults.

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